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dc.contributor.author | Mendoza Sepúlveda, Cristhian Alejandro | |
dc.date.accessioned | 2024-09-12T03:37:28Z | |
dc.date.available | 2024-09-12T03:37:28Z | |
dc.date.issued | 2017-06-15 | |
dc.identifier.issn | 0014-4886 | |
dc.identifier.other | ORCID: /0000-0002-5038-0991/work/89809599 | |
dc.identifier.uri | https://repositorio.uss.cl/handle/uss/11297 | |
dc.description.abstract | Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-like behavior and synaptic loss when co-administered during restraint stress, a model of PTSD and stress-induced depression, in mice. Here, we investigated the effects of post-treatment with intranasal cotinine on depressive- and anxiety-like behaviors, visual recognition memory as well as the number and morphology of GFAP+ immunoreactive cells, in the hippocampus and frontal cortex of mice subjected to prolonged restraint stress. The results revealed that in addition to the mood and cognitive impairments, restraint stress induced a significant decrease in the number and arborization of GFAP+ cells in the brain of mice. Intranasal cotinine prevented these stress-derived symptoms and the morphological abnormalities GFAP+ cells in both of these brain regions which are critical to resilience to stress. The significance of these findings for the therapy of PTSD and depression is discussed. | es |
dc.language.iso | und | |
dc.source | Experimental Neurology | |
dc.title | Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice. | |
dc.type | Artículo | |
dc.identifier.doi | 10.1016/j.expneurol.2017.06.016 | |
dc.publisher.department | Facultad de Ciencias de la Salud | |
dc.publisher.department | Facultad de Medicina y Ciencia |
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