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dc.contributor.author | Torres, Rodrigo | |
dc.contributor.author | Hidalgo, Cecilia | |
dc.date.accessioned | 2024-09-12T03:37:37Z | |
dc.date.available | 2024-09-12T03:37:37Z | |
dc.date.issued | 2023-12 | |
dc.identifier.issn | 0143-4160 | |
dc.identifier.other | ORCID: /0000-0002-4328-2920/work/145949335 | |
dc.identifier.uri | https://repositorio.uss.cl/handle/uss/11307 | |
dc.description | Publisher Copyright: © 2023 Elsevier Ltd | |
dc.description.abstract | Ryanodine receptors (RyR) are intracellular Ca2+ channels localized in the endoplasmic reticulum, where they act as critical mediators of Ca2+-induced Ca2+ calcium release (CICR). In the brain, mammals express in both neurons, and non-neuronal cells, a combination of the three RyR-isoforms (RyR1–3). Pharmacological approaches, which do not distinguish between isoforms, have indicated that RyR-isoforms contribute to brain function. However, isoform-specific manipulations have revealed that RyR-isoforms display different subcellular localizations and are differentially associated with neuronal function. These findings raise the need to understand RyR-isoform specific transcriptional regulation, as this knowledge will help to elucidate the causes of neuronal dysfunction for a growing list of brain disorders that show altered RyR channel expression and function. | en |
dc.language.iso | eng | |
dc.relation.ispartof | vol. 116 Issue: Pages: | |
dc.source | Cell Calcium | |
dc.title | Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview | |
dc.identifier.doi | 10.1016/j.ceca.2023.102821 | |
dc.publisher.department | Facultad de Medicina y Ciencia |
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