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dc.contributor.author Diethelm, Benjamín
dc.contributor.author Lagos, Carlos F.
dc.contributor.author Recabarren-Gajardo, Gonzalo
dc.date.accessioned 2024-09-26T00:30:17Z
dc.date.available 2024-09-26T00:30:17Z
dc.date.issued 2018-06
dc.identifier.issn 1422-8599
dc.identifier.uri https://repositorio.uss.cl/handle/uss/12381
dc.description Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstract The title compound was prepared by the nucleophilic addition of hydroxylamine over 1-cyanoadamantane. The poor reactivity of the nitrile substrate, due to its scarcely electrophilic nature, prompted the need to employ several activating conditions. Energy supply via conventional heating, ultrasound, and microwave irradiation did not lead to product formation. Therefore, Lewis acid catalysis was attempted. Initial tests with ZnCl2 led to product formation in poor yields. Conversely, the use of AlCl3 led to the formation of the desired amidoxime in the moderate yield, which was further increased to an excellent yield by performing the reaction in a more concentrated medium. The structural identity of the title compound was proven by spectroscopic methods (IR, NMR). This compound was later employed as a starting material for the synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives as potential 11β-HSD1 inhibitors. en
dc.language.iso eng
dc.relation.ispartof vol. 2018 Issue: no. 2 Pages:
dc.source MolBank
dc.title 1-Adamantylamidoxime en
dc.type Artículo
dc.identifier.doi 10.3390/M992
dc.publisher.department Facultad de Medicina y Ciencia


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