Universidad San Sebastián  
 

Repositorio Institucional Universidad San Sebastián

Búsqueda avanzada

Descubre información por...

 

Título

Ver títulos
 

Autor

Ver autores
 

Tipo

Ver tipos
 

Materia

Ver materias

Buscar documentos por...




Mostrar el registro sencillo del ítem

dc.contributor.author Alvarez, Francisca
dc.contributor.author Muñoz, Francisca
dc.contributor.author Schilcher, Pierre
dc.contributor.author Imhof, Axel
dc.contributor.author Almouzni, Geneviève
dc.contributor.author Loyola, Alejandra
dc.date.accessioned 2024-09-26T00:32:29Z
dc.date.available 2024-09-26T00:32:29Z
dc.date.issued 2011-05-20
dc.identifier.issn 0021-9258
dc.identifier.uri https://repositorio.uss.cl/handle/uss/12526
dc.description.abstract Much progress has been made concerning histone function in the nucleus; however, following their synthesis, how their marking and subcellular trafficking are regulated remains to be explored. To gain an insight into these issues, we focused on soluble histones and analyzed endogenous and tagged H3 histones in parallel. We distinguished six complexes that we could place to account for maturation events occurring on histones H3 and H4 from their synthesis onward. In each complex, a different set of chaperones is involved, and we found specific post-translational modifications. Interestingly, we revealed that histones H3 and H4 are transiently poly-(ADP-ribosylated). The impact of these marks in histone metabolism proved to be important as we found that acetylation of lysines 5 and 12 on histone H4 stimulated its nuclear translocation. Furthermore, we showed that, depending on particular histone H3 modifications, the balance in the presence of the different translocation complexes changes. Therefore, our results enabled us to propose a regulatory means of these marks for controlling cytoplasmic/nuclear shuttling and the establishment of early modification patterns. en
dc.language.iso eng
dc.relation.ispartof vol. 286 Issue: no. 20 Pages: 17714-17721
dc.source Journal of Biological Chemistry
dc.title Sequential establishment of marks on soluble histones H3 and H4 en
dc.type Artículo
dc.identifier.doi 10.1074/jbc.M111.223453
dc.publisher.department Facultad de Medicina y Ciencia


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem