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dc.contributor.author Martin-Jiménez, Cynthia
dc.contributor.author Gaitán-Vaca, Diana Milena
dc.contributor.author Areiza, Natalia
dc.contributor.author Echeverria, Valentina
dc.contributor.author Ashraf, Ghulam Md
dc.contributor.author González, Janneth
dc.contributor.author Sahebkar, Amirhossein
dc.contributor.author Garcia-Segura, Luis Miguel
dc.contributor.author Barreto, George E.
dc.date.accessioned 2024-09-26T00:33:52Z
dc.date.available 2024-09-26T00:33:52Z
dc.date.issued 2019-02-01
dc.identifier.issn 0028-3835
dc.identifier.uri https://repositorio.uss.cl/handle/uss/12622
dc.description Publisher Copyright: © 2018 © 2018 S. Karger AG, Basel.
dc.description.abstract Traumatic brain injury (TBI) is a serious public health problem. It may result in severe neurological disabilities and in a variety of cellular metabolic alterations for which available therapeutic strategies are limited. In the last decade, the use of estrogenic compounds, which activate protective mechanisms in astrocytes, has been explored as a potential experimental therapeutic approach. Previous works have suggested estradiol (E2) as a neuroprotective hormone that acts in the brain by binding to estrogen receptors (ERs). Several steroidal and nonsteroidal estrogenic compounds can imitate the effects of estradiol on ERs. These include hormonal estrogens, phytoestrogens and synthetic estrogens, such as selective ER modulators or tibolone. Current evidence of the role of astrocytes in mediating protective actions of estrogenic compounds after TBI is reviewed in this paper. We conclude that the use of estrogenic compounds to modulate astrocytic properties is a promising therapeutic approach for the treatment of TBI. en
dc.language.iso eng
dc.relation.ispartof vol. 108 Issue: no. 2 Pages: 142-160
dc.source Neuroendocrinology
dc.title Astrocytes mediate protective actions of estrogenic compounds after traumatic brain injury en
dc.type Artículo de revisión
dc.identifier.doi 10.1159/000495078
dc.publisher.department Facultad de Ciencias de la Salud
dc.publisher.department Facultad de Medicina y Ciencia


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