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dc.contributor.author Torres, Angie K.
dc.contributor.author Jara, Claudia
dc.contributor.author Llanquinao, Jesús
dc.contributor.author Lira, Matías
dc.contributor.author Cortés-Díaz, Daniela
dc.contributor.author Tapia-Rojas, Cheril
dc.date.accessioned 2024-09-26T00:37:46Z
dc.date.available 2024-09-26T00:37:46Z
dc.date.issued 2023-03
dc.identifier.issn 1661-6596
dc.identifier.uri https://repositorio.uss.cl/handle/uss/12880
dc.description Publisher Copyright: © 2023 by the authors.
dc.description.abstract Aging is a physiological process that generates progressive decline in many cellular functions. There are many theories of aging, and one of great importance in recent years is the mitochondrial theory of aging, in which mitochondrial dysfunction that occurs at advanced age could be responsible for the aged phenotype. In this context, there is diverse information about mitochondrial dysfunction in aging, in different models and different organs. Specifically, in the brain, different studies have shown mitochondrial dysfunction mainly in the cortex; however, until now, no study has shown all the defects in hippocampal mitochondria in aged female C57BL/6J mice. We performed a complete analysis of mitochondrial function in 3-month-old and 20-month-old (mo) female C57BL/6J mice, specifically in the hippocampus of these animals. We observed an impairment in bioenergetic function, indicated by a decrease in mitochondrial membrane potential, O2 consumption, and mitochondrial ATP production. Additionally, there was an increase in ROS production in the aged hippocampus, leading to the activation of antioxidant signaling, specifically the Nrf2 pathway. It was also observed that aged animals had deregulation of calcium homeostasis, with more sensitive mitochondria to calcium overload and deregulation of proteins related to mitochondrial dynamics and quality control processes. Finally, we observed a decrease in mitochondrial biogenesis with a decrease in mitochondrial mass and deregulation of mitophagy. These results show that during the aging process, damaged mitochondria accumulate, which could contribute to or be responsible for the aging phenotype and age-related disabilities. en
dc.language.iso eng
dc.relation.ispartof vol. 24 Issue: no. 6 Pages:
dc.source International Journal of Molecular Sciences
dc.title Mitochondrial Bioenergetics, Redox Balance, and Calcium Homeostasis Dysfunction with Defective Ultrastructure and Quality Control in the Hippocampus of Aged Female C57BL/6J Mice en
dc.type Artículo
dc.identifier.doi 10.3390/ijms24065476
dc.publisher.department Facultad de Medicina y Ciencia


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