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dc.contributor.author Herlitz-Cifuentes, Herbert
dc.contributor.author Vejar, Camila
dc.contributor.author Flores, Alejandra
dc.contributor.author Jara, Paola
dc.contributor.author Bustos, Paulina
dc.contributor.author Castro, Irene
dc.contributor.author Poblete, Evelyn
dc.contributor.author Saez, Katia
dc.contributor.author Opazo, Marina
dc.contributor.author Gajardo, Jorge
dc.contributor.author Aguayo, Claudio
dc.contributor.author Nova-Lamperti, Estefania
dc.contributor.author Lamperti, Liliana
dc.date.accessioned 2024-09-26T00:39:38Z
dc.date.available 2024-09-26T00:39:38Z
dc.date.issued 2019-03-01
dc.identifier.issn 2079-6374
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13012
dc.description Publisher Copyright: © 2019 MDPI AG. All rights reserved.
dc.description.abstract Rheumatoid arthritis (RA) has been associated with a higher risk of developing cardiovascular (CV) diseases. It has been proposed that systemic inflammation plays a key role in premature atherosclerosis development, and is therefore crucial to determine whether systemic components from RA patients promotes endothelial cell-oxidative stress by affecting reactive oxygen species (ROS) and nitric-oxide (NO) production. The aim of this study was to evaluate whether plasma from RA patients impair NO synthesis and ROS production by using the cell-line ECV-304 as a biosensor. NO synthesis and ROS production were measured in cells incubated with plasma from 73 RA patients and 52 healthy volunteers by fluorimetry. In addition, traditional CV risk factors, inflammatory molecules and disease activity parameters were measured. Cells incubated with plasma from RA patients exhibited reduced NO synthesis and increased ROS production compared to healthy volunteers. Furthermore, the imbalance between NO synthesis and ROS generation in RA patients was not associated with traditional CV risk factors. Our data suggest that ECV-304 cells can be used as a biosensor of systemic inflammation-induced endothelial cell-oxidative stress. We propose that both NO and ROS production are potential biomarkers aimed at improving the current assessment of CV risk in RA. en
dc.language.iso eng
dc.relation.ispartof vol. 9 Issue: no. 1 Pages:
dc.source Biosensors
dc.title Plasma from patients with rheumatoid arthritis reduces nitric oxide synthesis and induces reactive oxygen species in a cell-based biosensor en
dc.type Artículo
dc.identifier.doi 10.3390/bios9010032
dc.publisher.department Facultad de Ciencias de la Salud


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