Corrigendum to : BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α: BH3-only controls the sustained signalling of IRE1α (The EMBO Journal, (2012), 31, 10, (2322-2335), 10.1038/emboj.2012.84)

Abstract

The journal was alerted to the claim that the IRE input panels are identical in Figure 1G. Since the IRE input panels show a high degree of similarity, the source data for both panels are published with this notice for the avoidance of doubt. The HSP90 blot looks very similar in Fig 3F and Fig S4A. The authors confirmed that they had stripped and re-probed the original HSP90 blot in Fig 3F and Fig S4A. Specifically, the membrane was probed with antibodies to IRE1, and HSP90, and then re-probed with anti-PERK antibodies. For that reason, HSP90 was presented in both figures because it is the same experiment. In the source data published with this correction, the authors have marked the original data with contrast boxes and arrows to indicate which blots were presented in the figure. The legends have been updated to state that a control originating from one blot is displayed in both figures. The authors acknowledge that they had removed one set of experimental conditions with wild-type parental DKO cells when preparing Fig 4A and state that this does not change the conclusions of the figure. The figure is herewith updated with a demarcating line and source data for the full experiment is published with this notice. All authors agree with this corrigendum. The authors apologize for any confusion caused by these errors.