Resumen: Background: Health-related quality of life (HRQoL) is an important predictor of health outcomes in chronic kidney disease (CKD) including those patients in renal replacement therapy. Its evaluation through validated questionnaires is essential for comprehensive care in people undergoing renal replacement therapy. Aim: To evaluate the quality of life in patients with CKD on peritoneal dialysis. Material and Methods: Descriptive cross-sectional study. The KDQOL-36 quality of life questionnaire was applied to 67 patients aged 55 ± 15 years, in peritoneal dialysis at a public hospital in Santiago. Scores range from 0 to 100, values greater than 50 represent a better HRQoL. Results: The burden, symptoms, and effects of kidney disease component of the survey had scores over 50. Women, people without diabetes, those actively working and those with better incomes reported a better HRQoL. Conclusions: These patients on peritoneal dialysis report a good quality of life, especially in the specific components of kidney disease.