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dc.contributor.author Villanueva, Rodrigo A.
dc.contributor.author Loyola, Alejandra
dc.date.accessioned 2024-09-26T00:43:33Z
dc.date.available 2024-09-26T00:43:33Z
dc.date.issued 2023-06
dc.identifier.issn 2227-9059
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13273
dc.description Publisher Copyright: © 2023 by the authors.
dc.description.abstract Hepatitis B virus (HBV) is an enveloped DNA human virus belonging to the Hepadnaviridae family. Perhaps its main distinguishable characteristic is the replication of its genome through a reverse transcription process. The HBV circular genome encodes only four overlapping reading frames, encoding for the main canonical proteins named core, P, surface, and X (or HBx protein). However, pre- and post-transcriptional gene regulation diversifies the full HBV proteome into diverse isoform proteins. In line with this, hepatitis B virus X protein (HBx) is a viral multifunctional and regulatory protein of 16.5 kDa, whose canonical reading frame presents two phylogenetically conserved internal in-frame translational initiation codons, and which results as well in the expression of two divergent N-terminal smaller isoforms of 8.6 and 5.8 kDa, during translation. The canonical HBx, as well as the smaller isoform proteins, displays different roles during viral replication and subcellular localizations. In this article, we reviewed the different mechanisms of pre- and post-transcriptional regulation of protein expression that take place during viral replication. We also investigated all the past and recent evidence about HBV HBx gene regulation and its divergent N-terminal isoform proteins. Evidence has been collected for over 30 years. The accumulated evidence simply strengthens the concept of a new paradigm of the canonical HBx, and its smaller divergent N-terminal isoform proteins, not only during viral replication, but also throughout cell pathogenesis. en
dc.language.iso eng
dc.relation.ispartof vol. 11 Issue: no. 6 Pages:
dc.source Biomedicines
dc.title Pre- and Post-Transcriptional Control of HBV Gene Expression : The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions en
dc.type Artículo de revisión
dc.identifier.doi 10.3390/biomedicines11061674
dc.publisher.department Facultad de Medicina y Ciencia


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