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dc.contributor.author Opazo-Capurro, Andrés
dc.contributor.author Morales-León, Felipe
dc.contributor.author Jerez, Christian
dc.contributor.author Olivares-Pacheco, Jorge
dc.contributor.author Alcalde-Rico, Manuel
dc.contributor.author González-Muñoz, Paulina
dc.contributor.author Bello-Toledo, Helia
dc.contributor.author Cardenas-Arias, Adriana
dc.contributor.author Esposito, Fernanda
dc.contributor.author Lincopán, Nilton
dc.contributor.author Illesca, Vijna
dc.contributor.author González-Rocha, Gerardo
dc.date.accessioned 2024-09-26T00:43:46Z
dc.date.available 2024-09-26T00:43:46Z
dc.date.issued 2022-09
dc.identifier.issn 2165-0497
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13287
dc.description Publisher Copyright: Copyright © 2022 Opazo-Capurro et al.
dc.description.abstract The aim of this study was to investigate the genomic features of an extensively drug-resistant (XDR) Pseudomonas aeruginosa isolate (P-469) emerging in Chile. Antibiotic susceptibility was determined by disk diffusion and “colistin agar” test. Whole-genome sequencing (WGS) was performed by the Illumina NextSeq 2000 platform, and epidemiologically and clinically relevant data (i.e., sequence-type, serotype, mobile genetic elements, virulome, resistome, plasmidome, prophages, and CRISPR-Cas systems) were retrieved using multiple bioinformatic tools. The P-469 strain displayed an XDR profile, remaining susceptible to colistin. Genomic analysis revealed that this isolate belonged to the “high-risk” clone ST654 (CC654), serotype O4, and genotype exoS+. Strikingly, two CRISPR-Cas systems, five intact prophages sequences, and a broad resistome that included blaNDM-1 and the novel blaVIM-80 carbapenemase genes were predicted. Our results revealed the genomic characteristics of P. aeruginosa belonging to the high-risk clone ST654/O4 coproducing NDM-1 and VIM-80 in Chile, supporting that genomic surveillance is necessary to track the emergence and spread of epidemiologically successful WHO’s critical priority pathogens in order to prevent their rapid dissemination. en
dc.language.iso eng
dc.relation.ispartof vol. 10 Issue: no. 5 Pages:
dc.source Microbiology Spectrum
dc.title Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa exoS+/O4 Strain Belonging to the “High-Risk” Clone ST654 and Coproducer of NDM-1 and the Novel VIM-80 en
dc.type Artículo
dc.identifier.doi 10.1128/spectrum.01439-22
dc.publisher.department Facultad de Medicina y Ciencia


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