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dc.contributor.author | Opazo-Capurro, Andrés | |
dc.contributor.author | Morales-León, Felipe | |
dc.contributor.author | Jerez, Christian | |
dc.contributor.author | Olivares-Pacheco, Jorge | |
dc.contributor.author | Alcalde-Rico, Manuel | |
dc.contributor.author | González-Muñoz, Paulina | |
dc.contributor.author | Bello-Toledo, Helia | |
dc.contributor.author | Cardenas-Arias, Adriana | |
dc.contributor.author | Esposito, Fernanda | |
dc.contributor.author | Lincopán, Nilton | |
dc.contributor.author | Illesca, Vijna | |
dc.contributor.author | González-Rocha, Gerardo | |
dc.date.accessioned | 2024-09-26T00:43:46Z | |
dc.date.available | 2024-09-26T00:43:46Z | |
dc.date.issued | 2022-09 | |
dc.identifier.issn | 2165-0497 | |
dc.identifier.uri | https://repositorio.uss.cl/handle/uss/13287 | |
dc.description | Publisher Copyright: Copyright © 2022 Opazo-Capurro et al. | |
dc.description.abstract | The aim of this study was to investigate the genomic features of an extensively drug-resistant (XDR) Pseudomonas aeruginosa isolate (P-469) emerging in Chile. Antibiotic susceptibility was determined by disk diffusion and “colistin agar” test. Whole-genome sequencing (WGS) was performed by the Illumina NextSeq 2000 platform, and epidemiologically and clinically relevant data (i.e., sequence-type, serotype, mobile genetic elements, virulome, resistome, plasmidome, prophages, and CRISPR-Cas systems) were retrieved using multiple bioinformatic tools. The P-469 strain displayed an XDR profile, remaining susceptible to colistin. Genomic analysis revealed that this isolate belonged to the “high-risk” clone ST654 (CC654), serotype O4, and genotype exoS+. Strikingly, two CRISPR-Cas systems, five intact prophages sequences, and a broad resistome that included blaNDM-1 and the novel blaVIM-80 carbapenemase genes were predicted. Our results revealed the genomic characteristics of P. aeruginosa belonging to the high-risk clone ST654/O4 coproducing NDM-1 and VIM-80 in Chile, supporting that genomic surveillance is necessary to track the emergence and spread of epidemiologically successful WHO’s critical priority pathogens in order to prevent their rapid dissemination. | en |
dc.language.iso | eng | |
dc.relation.ispartof | vol. 10 Issue: no. 5 Pages: | |
dc.source | Microbiology Spectrum | |
dc.title | Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa exoS+/O4 Strain Belonging to the “High-Risk” Clone ST654 and Coproducer of NDM-1 and the Novel VIM-80 | en |
dc.type | Artículo | |
dc.identifier.doi | 10.1128/spectrum.01439-22 | |
dc.publisher.department | Facultad de Medicina y Ciencia |
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