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dc.contributor.author Sharifi-Rad, Javad
dc.contributor.author Quispe, Cristina
dc.contributor.author Rahavian, Amirhossein
dc.contributor.author Pereira Carneiro, Joara Nályda
dc.contributor.author Rocha, Janaína Esmeraldo
dc.contributor.author Alves Borges Leal, Antônio Linkoln
dc.contributor.author Bezerra Morais Braga, Maria Flaviana
dc.contributor.author Melo Coutinho, Henrique Douglas
dc.contributor.author Ansari Djafari, Anahita
dc.contributor.author Alarcón-Zapata, Pedro
dc.contributor.author Martorell, Miquel
dc.contributor.author Antika, Gizem
dc.contributor.author Tumer, Tugba Boyunegmez
dc.contributor.author Cruz-Martins, Natália
dc.contributor.author Helon, Paweł
dc.contributor.author Paprocka, Paulina
dc.contributor.author Koch, Wojciech
dc.contributor.author Docea, Anca Oana
dc.contributor.author Calina, Daniela
dc.date.accessioned 2024-09-26T00:44:18Z
dc.date.available 2024-09-26T00:44:18Z
dc.date.issued 2021-08-24
dc.identifier.issn 1663-9812
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13322
dc.description Publisher Copyright: © Copyright © 2021 Sharifi-Rad, Quispe, Rahavian, Pereira Carneiro, Rocha, Alves Borges Leal, Bezerra Morais Braga, Melo Coutinho, Ansari Djafari, Alarcón-Zapata, Martorell, Antika, Tumer, Cruz-Martins, Helon, Paprocka, Koch, Docea and Calina.
dc.description.abstract Sexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was performed using databases and search engines such as PubMed, Scopus, Google Scholar and Science Direct. From the pharmacotherapeutic management point of view, any strategies for prevention should contain medical approaches. The bioactive compounds obtained from natural products have shown biological effects against different microorganisms for the treatment of these diseases. The main results showed antimicrobial, antiprotozoal, antifungal and antiviral effects such as HIV. Also, the molecular mechanisms, signalling pathways and action targets of natural compounds were highlighted, thus justifying bacterial and antifungal inhibition, apoptosis or reduction of viral replication. From the data of our study, we can conclude that natural compounds may be a significant source for adjuvant drugs / complementary therapies in the treatment of STDs. With all these benefits, the future must conduct extensive clinical trials and the development of pharmaceutical nanotechnologies for a greater therapeutic effect. en
dc.language.iso eng
dc.relation.ispartof vol. 12 Issue: Pages:
dc.source Frontiers in Pharmacology
dc.title Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management : A Review to Explore Molecular Mechanisms of Action en
dc.type Artículo de revisión
dc.identifier.doi 10.3389/fphar.2021.674682
dc.publisher.department Facultad de Ciencias de la Naturaleza
dc.publisher.department Facultad de Medicina Veterinaria


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