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dc.contributor.author Labarca, Gonzalo
dc.contributor.author Drake, Lauren
dc.contributor.author Horta, Gloria
dc.contributor.author Jantz, Michael A.
dc.contributor.author Mehta, Hiren J.
dc.contributor.author Fernandez-Bussy, Sebastian
dc.contributor.author Folch, Erik
dc.contributor.author Majid, Adnan
dc.contributor.author Picco, Michael
dc.date.accessioned 2024-09-26T00:45:27Z
dc.date.available 2024-09-26T00:45:27Z
dc.date.issued 2019-10-28
dc.identifier.issn 1471-2466
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13406
dc.description Publisher Copyright: © 2019 The Author(s).
dc.description.abstract Introduction: There is evidence of an association between inflammatory bowel disease (IBD) and lung conditions such as chronic obstructive pulmonary disease (COPD). This systematic review and meta-analysis explored the risk of new onset IBD in patients with COPD and new onset COPD in IBD patients. Methods: We performed a systematic review of observational studies exploring the risk of both associations. Two independent reviewers explored the EMBASE, MEDLINE, LILACS and DOAJ databases, and the risk of bias was evaluated using the ROBBINS-I tool. Data from included studies was pooled in a random effect meta-analysis following a DerSimonian-Laird method. The quality of the evidence was ranked using GRADE criteria. Results: Four studies including a pooled population of 1355 new cases were included. We found association between new onset IBD in COPD population. The risk of bias was low in most of them. Only one study reported tobacco exposure as a potential confounding factor. The pooled risk ratio (RR) for a new diagnosis of IBD in COPD patients was 2.02 (CI, 1.56 to 2.63), I 2 = 72% (GRADE: low). The subgroup analyses for Crohn's disease and ulcerative colitis yielded RRs of 2.29 (CI, 1.51 to 3.48; I 2 = 62%), and 1.79 (CI, 1.39 to 2.29; I 2 = 19%.), respectively. Discussion: According to our findings, the risk of new onset IBD was higher in populations with COPD compared to the general population without this condition. Based on our analysis, we suggest a potential association between IBD and COPD; however, further research exploring the potential effect of confounding variables, especially cigarette smoking, is still needed. en
dc.language.iso eng
dc.relation.ispartof vol. 19 Issue: no. 1 Pages:
dc.source BMC Pulmonary Medicine
dc.title Association between inflammatory bowel disease and chronic obstructive pulmonary disease : A systematic review and meta-analysis en
dc.type Artículo de revisión
dc.identifier.doi 10.1186/s12890-019-0963-y
dc.publisher.department Facultad de Medicina y Ciencia


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