Universidad San Sebastián  
 

Repositorio Institucional Universidad San Sebastián

Búsqueda avanzada

Descubre información por...

 

Título

Ver títulos
 

Autor

Ver autores
 

Tipo

Ver tipos
 

Materia

Ver materias

Buscar documentos por...




Mostrar el registro sencillo del ítem

dc.contributor.author Bustamante-Barrientos, Felipe A.
dc.contributor.author Luque-Campos, Noymar
dc.contributor.author Araya, María Jesús
dc.contributor.author Lara-Barba, Eliana
dc.contributor.author de Solminihac, Javiera
dc.contributor.author Pradenas, Carolina
dc.contributor.author Molina, Luis
dc.contributor.author Herrera-Luna, Yeimi
dc.contributor.author Utreras-Mendoza, Yildy
dc.contributor.author Elizondo-Vega, Roberto
dc.contributor.author Vega-Letter, Ana María
dc.contributor.author Luz-Crawford, Patricia
dc.date.accessioned 2024-09-26T00:46:42Z
dc.date.available 2024-09-26T00:46:42Z
dc.date.issued 2023-12
dc.identifier.issn 1479-5876
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13494
dc.description Publisher Copyright: © 2023, BioMed Central Ltd., part of Springer Nature.
dc.description.abstract Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current in vitro and in vivo approaches support that mitochondrial dysfunction is branded by several molecular and cellular defects, whose impact at different levels including the calcium and iron homeostasis, energetic balance and/or oxidative stress, makes it difficult to resolve them collectively given their multifactorial nature. Mitochondrial transfer offers an overall solution since it contains the replacement of damage mitochondria by healthy units. Therefore, this review provides an introducing view on the structure and energy-related functions of mitochondria as well as their dynamics. In turn, we summarize current knowledge on how these features are deregulated in different neurodegenerative diseases, including frontotemporal dementia, multiple sclerosis, amyotrophic lateral sclerosis, Friedreich ataxia, Alzheimer´s disease, Parkinson´s disease, and Huntington’s disease. Finally, we analyzed current advances in mitochondrial transfer between diverse cell types that actively participate in neurodegenerative processes, and how they might be projected toward developing novel therapeutic strategies. en
dc.language.iso eng
dc.relation.ispartof vol. 21 Issue: no. 1 Pages:
dc.source Journal of Translational Medicine
dc.title Mitochondrial dysfunction in neurodegenerative disorders : Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells en
dc.type Artículo de revisión
dc.identifier.doi 10.1186/s12967-023-04493-w
dc.publisher.department Facultad de Medicina y Ciencia


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem