Resumen: Introduction: People with Human Immunodeficiency Virus (HIV) require antiretroviral treatment (AT). Both cause oxidative stress (OS), nevertheless, sparse evidence exist concerning the level of OS and physical performance in this population. Objective: To characterize physical activity level, physical performance, oxidative stress and quality of life of patients with HID/AIDS treated with AT at Dr. Lucio Córdova Hospital. Methodology: Descriptive exploratory design. 26 male participants were included (26.3 ±3 years). AT use, substance consumption and immunological testing was registered. Weight, height, BMI and physical activity levels (IPAQ), physical performance (6MWT and sit-to-stand test), carbonilated proteins levels in blood and MOS-HIV questionnaire of quality of life were measured. Results: the sample showed on average 3759 ± 2486 mets/min/week, with a predominance of vigorous activity, a reduction of 7,24% in 6MWT, 19.58 ± 4.1 sit-to-stand repetitions in 30 seconds, augmented carbonilated proteins in 73% of patients and a diminished quality of life level (70/100 points). Conclusion: young male patients with HIV/AIDS showed high levels of self-reported physical activity and carbonilated proteins but diminished physical performance and quality of life.