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dc.contributor.author Covián, Camila
dc.contributor.author Fernández-Fierro, Ayleen
dc.contributor.author Retamal-Díaz, Angello
dc.contributor.author Díaz, Fabián E.
dc.contributor.author Vasquez, Abel E.
dc.contributor.author Lay, Margarita K.
dc.contributor.author Riedel, Claudia A.
dc.contributor.author González, Pablo A.
dc.contributor.author Bueno, Susan M.
dc.contributor.author Kalergis, Alexis M.
dc.date.accessioned 2024-09-26T00:49:38Z
dc.date.available 2024-09-26T00:49:38Z
dc.date.issued 2019-11-29
dc.identifier.issn 1664-3224
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13694
dc.description Publisher Copyright: © Copyright © 2019 Covián, Fernández-Fierro, Retamal-Díaz, Díaz, Vasquez, Lay, Riedel, González, Bueno and Kalergis.
dc.description.abstract The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a memory-like response in innate immune cells is known as “trained immunity.” Epigenetic reprogramming through histone modification in the regulatory elements of particular genes has been reported as one of the mechanisms associated with the induction of trained immunity in both, humans and mice. Indeed, it has been shown that BCG vaccination induces changes in the methylation pattern of histones associated with specific genes in circulating monocytes leading to a “trained” state. Importantly, these modifications can lead to the expression and/or repression of genes that are related to increased protection against secondary infections after vaccination, with improved pathogen recognition and faster inflammatory responses. In this review, we discuss BCG-induced cross-protection and acquisition of trained immunity and potential heterologous effects of recombinant BCG vaccines. en
dc.language.iso eng
dc.relation.ispartof vol. 10 Issue: Pages:
dc.source Frontiers in Immunology
dc.title BCG-Induced Cross-Protection and Development of Trained Immunity : Implication for Vaccine Design en
dc.type Artículo de revisión
dc.identifier.doi 10.3389/fimmu.2019.02806
dc.publisher.department Facultad de Ciencias para el Cuidado de la Salud


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