Universidad San Sebastián  
 

Repositorio Institucional Universidad San Sebastián

Búsqueda avanzada

Descubre información por...

 

Título

Ver títulos
 

Autor

Ver autores
 

Tipo

Ver tipos
 

Materia

Ver materias

Buscar documentos por...




Mostrar el registro sencillo del ítem

dc.contributor.author Vargas, C.
dc.contributor.author Balmaceda, C.
dc.contributor.author Rodríguez, F.
dc.contributor.author Rojas, R.
dc.contributor.author Giglio, A.
dc.contributor.author Espinoza, M. A.
dc.date.accessioned 2024-09-26T00:54:07Z
dc.date.available 2024-09-26T00:54:07Z
dc.date.issued 2019-09-03
dc.identifier.issn 1473-7167
dc.identifier.uri https://repositorio.uss.cl/handle/uss/13993
dc.description Publisher Copyright: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.abstract Background: Sunitinib and Pazopanib are two metastatic renal cell carcinoma (MRCC) treatment alternatives, however the health system in Chile does not consider coverage for any. The cost-effectiveness versus relevant comparator was assessed to support evidence-based decision making. Methods: A four health states Markov model was built: first, second line treatments, BSC and death. Benefits were measured in QALYs, and efficacy estimates were obtained from an indirect treatment comparison. A 10-year time horizon and a 3% undifferentiated discount rate were considered. Deterministic and probabilistic sensitivity analyses were performed. Results: The costs of treating MRCC with Sunitinib were higher than Pazopanib and BSC. When comparing Sunitinib versus Pazopanib, the incremental benefit is small favoring Sunitinib (0.03 QALYs). The base case scenario shows an average ICER of PA versus BSC of US$62,327.11/QALY and of US$85,885/QALY for Sunitinib versus Pazopanib. The ICER was most sensitive to the OS relative to BSC, where evidence was associated to important bias. Conclusions: Sunitinib or Pazopanib can be considered cost-effective if a 3 GDP per-capita threshold is assumed. The decision between SU or PA is highly sensitive to the price of the drugs, rather than the outcomes. Therefore, the decision might be made based on cost-minimization exercise. en
dc.language.iso eng
dc.relation.ispartof vol. 19 Issue: no. 5 Pages: 609-617
dc.source Expert Review of Pharmacoeconomics and Outcomes Research
dc.title Economic evaluation of sunitinib versus pazopanib and best supportive care for the treatment of metastatic renal cell carcinoma in Chile : cost-effectiveness analysis and a mixed treatment comparison en
dc.type Artículo
dc.identifier.doi 10.1080/14737167.2019.1580572
dc.publisher.department Facultad de Medicina y Ciencia


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem