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dc.contributor.author Alcala, Martin
dc.contributor.author Gutierrez-Vega, Sebastián
dc.contributor.author Castro, Erica
dc.contributor.author Guzman-Gutiérrez, Enrique
dc.contributor.author Ramos-Álvarez, Maria Pilar
dc.contributor.author Viana, Marta
dc.date.accessioned 2024-09-26T00:54:25Z
dc.date.available 2024-09-26T00:54:25Z
dc.date.issued 2018-11-06
dc.identifier.issn 1664-042X
dc.identifier.uri https://repositorio.uss.cl/handle/uss/14015
dc.description Publisher Copyright: Copyright © 2018 Alcala, Gutierrez-Vega, Castro.
dc.description.abstract The prevalence of obesity in women of childbearing age around the globe has dramatically increased in the last decades. Obesity is characterized by a low-state chronic inflammation, metabolism impairment and oxidative stress, among other pathological changes. Getting pregnant in this situation involves that gestation will occur in an unhealthy environment, that can potentially jeopardize both maternal and fetal health. In this review, we analyze the role of maternal obesity-induced oxidative stress as a risk factor to develop adverse outcomes during gestation, including reduced fertility, spontaneous abortion, teratogenesis, preeclampsia, and intrauterine growth restriction. Evidences of macromolecule oxidation increase in reactive oxygen species generation and antioxidant defense alterations are commonly described in maternal and fetal tissues. Thus, antioxidant supplementation become an interesting prophylactic and therapeutic tool, that yields positive results in cellular, and animal models. However, the results from most meta-analysis studying the effect of these therapies in complicated gestations in humans are not really encouraging. It is still to be analyzed whether these therapies could work if applied to cohorts of patients at a high risk, such as those with low concentration of antioxidants or obese pregnant women. en
dc.language.iso eng
dc.relation.ispartof vol. 9 Issue: no. NOV Pages:
dc.source Frontiers in Physiology
dc.title Antioxidants and oxidative stress : Focus in obese pregnancies en
dc.type Artículo de revisión
dc.identifier.doi 10.3389/fphys.2018.01569
dc.publisher.department Facultad de Medicina y Ciencia


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